The Iranian regime has dismissed President Trump's threats to crush Iran economically, saying that years of U.S. sanctions have failed.

(Image credit: Hadi Mizban)

President Trump announced this week that the U.S. will be imposing the "most crushing economic operation" against Iran.

NPR's Sacha Pfeiffer talks to Miad Maleki, a former Treasury official who designed pressure campaigns for Iran, about the potential effectiveness of President Trump's pivot to "economic warfare."

As President Trump tries to disengage from the war he launched on Iran, Gulf allies worry about their own future with their powerful neighbor.

NPR's Leila Fadel asks historian Bader Al-Saif about how Gulf leaders contend with President Trump's approach to Iran.

The Israeli military has ordered rare criminal investigations into two deadly incidents during the Gaza war, including the killing of a 5-year-old girl, her family and the medics sent to rescue her.

Israel's military on Wednesday announced its first criminal investigations into troop conduct in Gaza, focusing on the killings of 5-year-old Hind Rajab and her family and of 15 Palestinian paramedics.

(Image credit: Jehad Alshrafi)

Israel is launching a criminal investigation into the Gaza killings carried out by Israeli troops of a 5-year-old girl and her family and the medics sent to rescue her.

Defense analyst Stacie Pettyjohn says while the U.S. military is facing long-range missile shortages, prolonged deployments and vacated regional bases, Iran is building cheaper weapons quickly.

Israel struck an air base in northwest Syria early Tuesday, saying it aimed to prevent Turkish troops from deploying there. Turkey, which has close ties with the Syrian government and has been providing assistance to Syria's military.

(Image credit: AP Photo)

Iraq's new prime minister faces a huge dilemma in promising President Trump he will disarm Iran-backed militias by Sept. 30

The Iran war is putting Gulf countries in a bind. They want the U.S. as a security partner, but they also have to live with Iran as a neighbor.

A marathon meeting between President Trump's envoy Jared Kushner and Israel's prime minister ended without firm commitment to the latest U.S. plan for a Gaza ceasefire.

President Trump's envoy Jared Kushner met with Israel's prime minister in an effort to revive the stalled Gaza agreement. NPR's Michel Martin talks to former U.S. ambassador to Israel Daniel Shapiro.

NPR's Michel Martin speaks with Michael Fuchs, director at the Open Society Foundation and a former State Department official, about President Trump's threat to bomb Oman, an ally of the U.S.

The Palestinian American whose home in the occupied West Bank has been besieged by Israeli settlers traveled to his property on Monday to join other family members who have been defending it.

(Image credit: Majdi Mohammed)

The family of a Palestinian-American man remain holed up in his West Bank home for more than a week, after Israeli settlers laid siege to the house and the Israeli army then turned it into a closed military area.

President Trump's son-in-law Jared Kushner is trying to move Gaza talks forward. He met with Israeli Prime Minister Benjamin Netanyahu a day after meeting with Hamas, but key disagreements remain.

President Trump's Middle East negotiator is in the region for talks on the future of Gaza. We look at where negotiations stand.

Palestinian and Arab minority parties in Israel are gearing up for "the mother of all elections" this fall, as they try to oust a right-wing government they say is racist and a threat to their safety. Their biggest challenge may be divisions amongst themselves, however.