Pope Leo XIV will need no further treatment for lung cancer after final tests confirmed the disease was localized, his doctors said Wednesday.

Dr. Luigi Carbone and Professor Stefano Margaritora announced the findings just over a week after surgeons removed a tumor from the pontiff’s right lung.

"The final histopathology and molecular testing reports on the tissue removed during the Holy Father’s surgery were issued today," the doctors said in a statement.

POPE LEO WELCOMED BACK AS HE DELIVERS ANGELUS PRAYER DAYS AFTER LUNG CANCER SURGERY

"The results confirmed that the tumor was a lung adenocarcinoma and that the disease was localized. A subsequent oncological assessment has confirmed that no further treatment is necessary."

Pope Leo underwent surgery Oct. 13 at Rome’s Gemelli Hospital. The operation lasted about 90 minutes, with the pope spending approximately three hours in the operating room, according to the Holy See.

"The doctors said it was successful and there were no complications," the Holy See press office said after the procedure.

The pontiff awoke normally and returned to his hospital room following a brief observation period, Vatican News reported.

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He was discharged Saturday after blood tests and a chest X-ray confirmed he was well enough to return to the Vatican. Thousands of supporters gathered outside the hospital, shouting "Papa!" as he departed.

Before leaving, Leo visited the children’s oncology ward, where young patients had sent him letters during his hospital stay.

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"Pope Leo, our prayers are for you," a girl named Eleonora wrote in a letter released by Vatican News.

"May God, the Most Holy Virgin, and the guardian angels always protect you," she added.

Eleonora’s mother told the pope her daughter was now healthy, according to the Vatican.

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"Faith moves mountains," Eleonora wrote. "God has heard our prayers."

Fox News Digital's Robert McGreevy contributed to this report.

Pope Leo XIV made a remarkable return to the Vatican on Sunday, appearing before thousands of Catholic faithful in St. Peter's Square just five days after undergoing surgery to remove a cancerous tumor from his lung.

The 71-year-old pontiff delivered his traditional Angelus prayer from a window overlooking the square, marking his first official engagement since being discharged Saturday from Rome's Gemelli hospital, where doctors removed the lower lobe of his right lung.

Leo thanked the faithful for their prayers and support throughout his hospitalization, saying his recent health struggles had brought him closer to those suffering from illness. He also expressed gratitude to the doctors, nurses and hospital staff who cared for him following the operation.

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The first American-born pope said he planned to gradually resume his regular activities with God's help and the continued prayers of the faithful.

During his Angelus address, Leo reflected on one of Jesus' best-known teachings, "Give therefore to the emperor the things that are the emperor's, and to God the things that are God's," urging Christians to live with integrity and resist hypocrisy.

His return came sooner than expected after doctors initially anticipated a hospital stay of approximately one week following Tuesday's surgery.

As he departed the hospital on Saturday, the pope told a reporter in English that he was doing "much better."

Claire Holland, visiting from Jacksonville, Fla., told The Associated Press she felt "very blessed" to witness the pope's return.

"I think there have been millions and millions of prayers. And he is a strong determined man, and I am so happy that he is feeling well enough to do this," Holland said.

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The surgery marked the first major health crisis of Leo's 17-month pontificate. Doctors confirmed that the tumor was adenocarcinoma, the most common form of lung cancer.

Doctors are conducting further testing on the tumor and surrounding lymph nodes to determine the extent of the disease and whether additional treatment, including chemotherapy, immunotherapy or targeted therapy, may be necessary.

The pope is scheduled to visit Uruguay, Argentina and Peru from Nov. 6 through Nov. 17, a demanding itinerary that includes a dozen flights and two helicopter rides to high-altitude destinations.

His surgeon, Dr. Stefano Margaritora, told Vatican News on Saturday that the pope appears well enough to go on the trip.

"The Holy Father has put his heart and soul into his recovery," Margaritora said, adding that he expected Leo to recover fully from the surgery "in another 10 days or so."

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"As for a long trip involving air travel in about three weeks, I would say there are no clinical reasons why it should not take place," Margaritora said.

Fox News’ Courtney Walsh and The Associated Press contributed to this report.