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Christina Applegate says she was misdiagnosed and does not have MS

Applegate revealed that despite the misdiagnosis, she still has "every symptom of someone with MS," adding, "I still have to use wheelchairs when I go to the doctor's office. I can't walk from the car to the room."

Actor Christina Applegate reveals she was misdiagnosed with multiple sclerosis

20 October 2026 at 14:51

The Married … With Children actor says the news is ‘unnerving’ and ‘really confusing’

After becoming a prominent advocate for multiple sclerosis awareness and chronicling her struggles in an emotional memoir published in March, the Emmy-winning actor Christina Applegate has revealed she does not have the debilitating autoimmune disease after all.

Applegate, 54, made the stunning announcement in an episode of her podcast MeSsy, recorded with fellow actor Jamie-Lynn Sigler, posted to YouTube on Tuesday.

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© Photograph: Gilbert Flores/Variety/Getty Images

© Photograph: Gilbert Flores/Variety/Getty Images

© Photograph: Gilbert Flores/Variety/Getty Images

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