• Christina Applegate recently learned that she was misdiagnosed with multiple sclerosis (MS).
• Applegate was first diagnosed in 2021 after multiple tests and worsening symptoms.
• About 15% of MS patients are believed to be misdiagnosed, given how complex the disorder is.

After being diagnosed with multiple sclerosis (MS) in 2021, living with severe symptoms, and becoming one of the most famous celebrities with the disorder, Christina Applegate learned some shocking news: She doesn't actually have MS.

In an October 20, two-part episode of her podcast "MeSsy" with Jamie Lynn Sigler (another actor diagnosed with MS), Applegate shared that she took over half a year off from recording the podcast to process the news of her MS misdiagnosis.

According to Applegate, her doctor framed the revelation as a positive update. "She came into my room and said, 'Congratulations, you don't have MS,'" Applegate said in the podcast.

But to Applegate, no longer having an explanation for the pain, balance issues, tremors, incontinence, and fatigue she'd been living with for years felt more like being "back at square one."

"You don't get misdiagnosed and then all of a sudden, I'm better," she said. "If anything, I've gotten worse, in some ways."

Applegate's story is far from a medical anomaly. MS researchers estimate that about 15% of worldwide MS patients are actually misdiagnosed, based on a 2024 meta-analysis of multiple studies.

The risks to patients are two-fold, Dr. Marwa Kaisey, an associate professor of neurology at Cedars-Sinai, who also appeared on the podcast, told Business Insider. "One is thinking you have MS — a lot of the medications we use to treat MS have side effects and risks like infections," she said. "The other category is, if you don't know what you have, then you're not getting treated for your actual diagnosis."

Kaisey and another researcher shared why MS is so challenging to diagnose — and why more people might end up with Applegate's experience in the future.

The race to diagnose a hard-to-diagnose disorder

There is no single blood test that can diagnose MS.

Instead, doctors often piece together an MS diagnosis using a neurological exam (testing balance and reflexes), MRI scans, a lumbar puncture (or spinal tap), and possible blood tests to rule out other conditions such as Lyme disease.

Sometimes, doctors overrely on a single diagnostic, such as an MRI finding, without performing enough other tests, Dr. Andrew J. Solomon, a professor of neurological sciences at the University of Vermont who co-authored the meta-analysis, told Business Insider.

In 2019, Solomon co-authored an MS misdiagnosis study that found that patients who were initially diagnosed with MS were later told they actually had other conditions, such as migraine, radiologically isolated syndrome, spondylopathy, and neuropathy, which can share overlapping symptoms with MS and similar brain scan results.

In the podcast, Applegate revealed that she had a nerve test to rule out peripheral neuropathy, as well as MRIs and a lumbar puncture. While her spinal fluid test showed a low level of immune proteins that can support an MS diagnosis, she had nearly 40 brain lesions and worsening symptoms, leading doctors to diagnose her with MS.

Solomon said MS should be diagnosed by "confirming each element of our diagnostic criteria and ruling out other things," rather than assuming it must be MS if the MRIs and symptoms fit.

The problem is, both physicians and patients are eager to diagnose MS as early as possible, he said. Correctly spotting MS early can lead to better treatment results and a higher likelihood of disability prevention, according to research.

Plus, for patients dealing with a plethora of debilitating symptoms, "a period of diagnostic uncertainty is uncomfortable," he said, even though the best course of action is to wait and perform more tests.

A new testing protocol revealed Applegate's misdiagnosis

In the podcast, Applegate shared that her brain lesions were missing "strings" associated with MS.

It's a finding associated with a new, more accurate diagnostic tool for Kaisey, who also co-authored the 2019 study with Solomon, explained on the podcast.

The central vein sign (CVS), is an MRI biomarker that can help differentiate MS brain lesions from ones associated with other disorders. It refers to a small vein that appears as a dot or thin line through the center of a brain lesion.

CVS was only recently adopted as part of the recommended MS diagnostic criteria, in 2025 — four years after Applegate was first diagnosed with MS. Kaisey told Business Insider that part of her work is expanding education around newer diagnostic tools, noting that not all physicians are using CVS yet.

Solomon hopes more doctors will include CVS in their diagnostic protocols, especially for existing MS patients or those who switch providers without being evaluated by their current doctors. "If something doesn't fit, there's an opportunity there to reevaluate if the diagnosis is right," he said.

Many misdiagnosed MS patients feel exactly like Applegate does

When it comes to learning about an MS misdiagnosis, Solomon said experiences like Applegate's aren't that uncommon.

"I've heard many stories where some doctor was very enthusiastic about telling a patient they actually didn't have MS," he said. "But many of these patients are suffering, and they still have symptoms. So it's not always necessarily a happy thing."

For Applegate, her initial MS diagnosis provided clarity and direction. "That was my answer to everything that was going on," Applegate said. Some might relate to Applegate's "square one" feeling, particularly if their doctor was an MS specialist and won't see them anymore, Solomon said. Without a formal diagnosis, they might also worry about insurance coverage for treatments that have provided some relief.

There is also the emotional part of having an MS diagnosis. "I leaned into other friends, I leaned into the community," Applegate said. "I had a reason as to why my day sucked every day, and now I don't have a reason."

Knowing she doesn't have MS also made her feel like she "let everybody down" after becoming one of the "poster children for MS," she said. It made her wonder if she was somehow imagining symptoms or at fault for her pain.

Given how common MS misdiagnosis is, Solomon believes it's a good thing that Applegate is sharing her story.

"It's kind of wonderful that Ms. Applegate is public with this because if the number is really 15%, you can do the math," he said. "There are a lot of people out there who might ask their doctors about the accuracy of their diagnosis and find out that, in fact, they had something else."

Olivia Colman goes vulpine, Rupert Grint’s newborn is a monster and Joko Anwar makes a warmhearted violent ghost story set in an Indonesian prison

If I’d ever wanted children, the films showing at the 59th edition of the International Fantastic film festival of Catalonia in the coastal town of Sitges, south of Barcelona, would have soon set me straight. This year’s recurring themes were explosive parturition, chewed-up nipples and the fruit of the womb turning out to be at best sociopathic, at worst inhuman.

The theme was celebrated in an evil-kiddy exhibition at the Miramar Cultural Centre, marking the 50th anniversary of Narciso Ibáñez Serrador’s “fantaterror” classic Who Can Kill a Child?, some of which was filmed in Sitges itself. The expo traced the subgenre from 1956’s The Bad Seed, via Rosemary’s Baby and The Exorcist, to this year’s Nightborn, in which poor Rupert Grint, as the hapless husband, is no match for the developing folk-horror bond between his depressed wife, their newborn “child”, and the spooky forest surrounding their house. Finnish director Hanna Bergholm, in her introduction, confessed it was inspired by her experiences of motherhood. Only up to a point, one hopes.

Helicopters rescued people stranded on rooftops as torrential rain swept across eastern Spain on Monday. Floods and storms killed at least four people, and shelter-in-place orders remained in force for more than 80,000 people. The downpour from Storm Adam cut off several towns along the Mediterranean coast as rivers overflowed their banks and streets turned into rivers. More than 2,000 people were evacuated, mainly in Oliva, and authorities carried out nearly 496 rescues in Valencia and Alicante, the Civil Guard police said

Spanish police sources say roughly 70 percent of recent asylum applications filed by Moroccan migrants in the North African enclave of Ceuta now claim persecution based on their homosexuality, a sharp change from the economic motives cited in the weeks after a large irregular entry in late July.

The report from Spanish newspaper ABC, citing Spanish National Police sources, also indicated that about 95 percent of the applications under review involve Moroccan nationals, and of those already decided, the rejection rate is estimated at about 99 percent.

Police have knowledge of at least 19 favorable decisions for people who entered during the July episode; five of those rested on sexual-orientation grounds.

The Unified Police Union (SUP) representative in Ceuta, Raúl Piera, told local media the share citing homosexuality has risen as high as 90 percent in the most recent filings. Applicants initially mentioned unemployment, family reunification or other reasons, he said.

After word circulated that economic grounds were unlikely to succeed, the accounts shifted.

“At first, they were not informed and did not know what they should say. But word spread,” Piera said.

Police sources have also raised the possibility that some applicants received advice, including from NGOs, on which grounds might improve their chances. While no fraud has been proven, the overwhelming amount of applications based on claims of homosexuality raises various red flags about the asylum application process.

Same-sex sexual relations are criminalized in Morocco under Article 489 of the penal code, which provides for prison terms of six months to three years. Spanish and European rules treat a well-founded fear of persecution on grounds of sexual orientation as a potential basis for protection.

Declaring oneself homosexual is not sufficient, however. Authorities examine the consistency of each account, personal circumstances and the risk upon return through interviews and documentation.

Interior Minister Fernando Grande-Marlaska, speaking in Ceuta, said a mere allegation is not enough: there must be “a principle of objective and clear proof” and “a minimum of serious evidence.”

Nearly 1,200 international-protection applications have been formalized since the late-July arrivals, of which roughly 700 have been resolved, according to government figures. An estimated 10,000 of those who crossed on July 30-31 remain in Ceuta, some in informal housing or remote areas. Many others have returned to Morocco voluntarily or through other processes.

The asylum claims continue to be assessed individually by the Office of Asylum and Refuge. Rejection does not automatically result in immediate removal; applicants must be notified, and some may abscond or challenge decisions in court, though the share pursuing judicial appeals has been described as very low.

The post Spain: 70% of migrants in Ceuta are claiming to be homosexuals in recent asylum applications appeared first on Remix News.

An intense Monday downpour at the Spanish exclave of Ceuta pushed feces and waste left by invading illegal migrants around the city's drains and into the sea, local outlets reported.

The post Besieged Ceuta Awash with Feces and Trash Left by Invading Illegals appeared first on Breitbart.