An explosion hit the 75th Arsenal, a Russian army plant in Serpukhov south of Moscow, overnight on 22 October, Russian Telegram channel Astra reported. Russian officials also claimed drone attacks on the Moscow region, Tula, and Lipetsk that night.

As Russia presses its full-scale invasion, Ukraine’s long-range drones and missiles keep hitting military plants and refineries deep inside Russia. Ukrainian outlet Militarnyi says this plant specializes in repairing Buk and S-300 air defense systems. Astra describes it more broadly, as making weapons and ammunition and repairing military equipment. If Militarnyi is right, the blast hit a site that fixes Russian air defenses. It came the night Moscow’s mayor credited air defenses with stopping hundreds of drones.

Blast at the arsenal

An Astra OSINT analyst placed the explosion inside the site from a video, the channel said. Residents claimed in local chats that blasts followed passing drones, then at least three missiles. Astra did not confirm the missile count. Serpukhov lies about 99 km south of Moscow. Ukraine has sanctioned the plant, and the US Treasury has listed it too. As of the morning of 22 October, no Russian official had confirmed the blast.

More footage of the attack on the arsenal in Serpukhov. We are awaiting satellite images. pic.twitter.com/tTsgc18W3L

— Exilenova+ (@Exilenova_plus) October 22, 2026

630 drones, by Moscow’s count

Moscow Mayor Sergei Sobyanin claimed that 630 drones flew toward the Moscow region from 20:30 on 21 October to 04:00 on 22 October. He claimed most were destroyed far out and 163 were neutralized on approach to Moscow. Two people were injured in Voronovo, in New Moscow, he stated.

Tula Oblast Governor Dmitry Milyaev claimed air defenses downed 70 Ukrainian drones over his region. Private homes were damaged in Tula and the Zaoksky district, he stated.

Lipetsk governor claims homes and a clinic damaged

Earlier in the night, Ukrainian monitoring channel Exilenova+ posted footage of commotion in Lipetsk after explosions. Lipetsk Oblast Governor Igor Artamonov claimed a drone strike damaged homes, apartment blocks, and a closed polyclinic. A man born in 2001 was injured and hospitalized, Artamonov claimed.

Lipetsk, moment of the explosion. https://t.co/wCX6GVThQr pic.twitter.com/bGwGLbUm2d

— Exilenova+ (@Exilenova_plus) October 21, 2026

In May, Ukrainian intelligence said Russia was deploying more regiments against strike drones. In September, Ukrainian units hit more Russian air defense systems and radars than in any month since 2024, Ukraine’s Defense Ministry said. Analyst Oleksandr Kovalenko counted 76 destroyed in September with days of the month still to go and argued Russia cannot replace such losses. If Militarnyi’s description holds, losing repair capacity would deepen that gap.