• Christina Applegate recently learned that she was misdiagnosed with multiple sclerosis (MS).
• Applegate was first diagnosed in 2021 after multiple tests and worsening symptoms.
• About 15% of MS patients are believed to be misdiagnosed, given how complex the disorder is.

After being diagnosed with multiple sclerosis (MS) in 2021, living with severe symptoms, and becoming one of the most famous celebrities with the disorder, Christina Applegate learned some shocking news: She doesn't actually have MS.

In an October 20, two-part episode of her podcast "MeSsy" with Jamie Lynn Sigler (another actor diagnosed with MS), Applegate shared that she took over half a year off from recording the podcast to process the news of her MS misdiagnosis.

According to Applegate, her doctor framed the revelation as a positive update. "She came into my room and said, 'Congratulations, you don't have MS,'" Applegate said in the podcast.

But to Applegate, no longer having an explanation for the pain, balance issues, tremors, incontinence, and fatigue she'd been living with for years felt more like being "back at square one."

"You don't get misdiagnosed and then all of a sudden, I'm better," she said. "If anything, I've gotten worse, in some ways."

Applegate's story is far from a medical anomaly. MS researchers estimate that about 15% of worldwide MS patients are actually misdiagnosed, based on a 2024 meta-analysis of multiple studies.

The risks to patients are two-fold, Dr. Marwa Kaisey, an associate professor of neurology at Cedars-Sinai, who also appeared on the podcast, told Business Insider. "One is thinking you have MS — a lot of the medications we use to treat MS have side effects and risks like infections," she said. "The other category is, if you don't know what you have, then you're not getting treated for your actual diagnosis."

Kaisey and another researcher shared why MS is so challenging to diagnose — and why more people might end up with Applegate's experience in the future.

The race to diagnose a hard-to-diagnose disorder

There is no single blood test that can diagnose MS.

Instead, doctors often piece together an MS diagnosis using a neurological exam (testing balance and reflexes), MRI scans, a lumbar puncture (or spinal tap), and possible blood tests to rule out other conditions such as Lyme disease.

Sometimes, doctors overrely on a single diagnostic, such as an MRI finding, without performing enough other tests, Dr. Andrew J. Solomon, a professor of neurological sciences at the University of Vermont who co-authored the meta-analysis, told Business Insider.

In 2019, Solomon co-authored an MS misdiagnosis study that found that patients who were initially diagnosed with MS were later told they actually had other conditions, such as migraine, radiologically isolated syndrome, spondylopathy, and neuropathy, which can share overlapping symptoms with MS and similar brain scan results.

In the podcast, Applegate revealed that she had a nerve test to rule out peripheral neuropathy, as well as MRIs and a lumbar puncture. While her spinal fluid test showed a low level of immune proteins that can support an MS diagnosis, she had nearly 40 brain lesions and worsening symptoms, leading doctors to diagnose her with MS.

Solomon said MS should be diagnosed by "confirming each element of our diagnostic criteria and ruling out other things," rather than assuming it must be MS if the MRIs and symptoms fit.

The problem is, both physicians and patients are eager to diagnose MS as early as possible, he said. Correctly spotting MS early can lead to better treatment results and a higher likelihood of disability prevention, according to research.

Plus, for patients dealing with a plethora of debilitating symptoms, "a period of diagnostic uncertainty is uncomfortable," he said, even though the best course of action is to wait and perform more tests.

A new testing protocol revealed Applegate's misdiagnosis

In the podcast, Applegate shared that her brain lesions were missing "strings" associated with MS.

It's a finding associated with a new, more accurate diagnostic tool for Kaisey, who also co-authored the 2019 study with Solomon, explained on the podcast.

The central vein sign (CVS), is an MRI biomarker that can help differentiate MS brain lesions from ones associated with other disorders. It refers to a small vein that appears as a dot or thin line through the center of a brain lesion.

CVS was only recently adopted as part of the recommended MS diagnostic criteria, in 2025 — four years after Applegate was first diagnosed with MS. Kaisey told Business Insider that part of her work is expanding education around newer diagnostic tools, noting that not all physicians are using CVS yet.

Solomon hopes more doctors will include CVS in their diagnostic protocols, especially for existing MS patients or those who switch providers without being evaluated by their current doctors. "If something doesn't fit, there's an opportunity there to reevaluate if the diagnosis is right," he said.

Many misdiagnosed MS patients feel exactly like Applegate does

When it comes to learning about an MS misdiagnosis, Solomon said experiences like Applegate's aren't that uncommon.

"I've heard many stories where some doctor was very enthusiastic about telling a patient they actually didn't have MS," he said. "But many of these patients are suffering, and they still have symptoms. So it's not always necessarily a happy thing."

For Applegate, her initial MS diagnosis provided clarity and direction. "That was my answer to everything that was going on," Applegate said. Some might relate to Applegate's "square one" feeling, particularly if their doctor was an MS specialist and won't see them anymore, Solomon said. Without a formal diagnosis, they might also worry about insurance coverage for treatments that have provided some relief.

There is also the emotional part of having an MS diagnosis. "I leaned into other friends, I leaned into the community," Applegate said. "I had a reason as to why my day sucked every day, and now I don't have a reason."

Knowing she doesn't have MS also made her feel like she "let everybody down" after becoming one of the "poster children for MS," she said. It made her wonder if she was somehow imagining symptoms or at fault for her pain.

Given how common MS misdiagnosis is, Solomon believes it's a good thing that Applegate is sharing her story.

"It's kind of wonderful that Ms. Applegate is public with this because if the number is really 15%, you can do the math," he said. "There are a lot of people out there who might ask their doctors about the accuracy of their diagnosis and find out that, in fact, they had something else."

Democratic US Senate nominee and vocal Israel critic compares Jewish state to a friend who pits one against their other friends

A changing of the congressional guard in January could leave room for meddling, though most legal scholars doubt it would happen.

© Kenny Holston/The New York Times

Atleta do Karate Clube de Faro volta a brilhar ao mais alto nível internacional, depois de se ter sagrado Campeã da Europa em fevereiro. A atleta Madalena Santos, do Karate Clube de Faro, conquistou a medalha de bronze na categoria de Kumite Cadetes Feminino +61 kg, no Campeonato do Mundo de Cadetes, Juniores e Sub-21 […]

Hollywood's favorite M&A target that never seems to get snapped up has a reported offer.

Applegate revealed that despite the misdiagnosis, she still has "every symptom of someone with MS," adding, "I still have to use wheelchairs when I go to the doctor's office. I can't walk from the car to the room."

Key developments on Oct. 20:

• Ukrainian strikes on Yandex data centers disrupt Russian court hearings, media reports
• Ukraine's HUR claims 108 Russian soldiers killed, 29 captured in Sumy Oblast operation
• Power outages in half of Ukraine's oblasts after Russian assault on power plants
• Fire at oil

Christina Applegate no tiene esclerosis múltiple: su diagnóstico fue un error. La actriz ha dado la noticia en su pódcast, llamado MeSsy, que presenta junto a la también actriz y paciente de esclerosis, Jamie Lynn Sigler. En él ha contado, este martes, que los médicos se equivocaron en su diagnóstico, hace cinco años. Y que eso, lejos de liberarla, no la ha hecho nada feliz.

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© Gilbert Flores (Variety via Getty Images)

Redfin's 2026 analysis ranks the 10 U.S. cities where the payment on a typical home eats the biggest share of income.

A seguradora francesa CNP Assurances anunciou esta terça-feira um acordo para comprar a Prudential do Brasil e a Prudential do México por cerca de 4 mil milhões de dólares (3,5 mil milhões de euros), pagos em dinheiro. A operação reforça a posição da seguradora francesa na América Latina e marca a sua entrada no mercado mexicano. A transação está sujeita a autorizações regulatórias e deverá ficar concluída no segundo semestre de 2027.

A CNP já é a terceiro maior grupo segurador brasileiro, graças sobretudo à parceria de distribuição com a Caixa Económica Federal. A aquisição da Prudential acrescenta-lhe uma operação relevante de seguros de pessoas, com uma rede de cerca de 2.500 agentes franchisados, conhecidos como Life Planners. A CNP, detida a 100% pelo Estado francês através de La Banque Postale, estima uma taxa interna de rentabilidade de 15% para a aquisição e um impacto negativo de cerca de 20 pontos percentuais no rácio de cobertura do capital regulamentar SCR. No anúncio da aquisição, a CNP Assurances indicou para a Prudential receitas de 1,3 mil milhões de euros para a operação brasileira e de 100 milhões para a mexicana.

A CNP no Brasil vende seguros de vida, seguros associados ao crédito, seguros habitacionais e outros produtos. A oferta inclui ainda previdência privada, capitalização e consórcios, dependendo da sociedade e da parceria comercial. Na Caixa Vida e Previdência, em parceria com a Caixa Seguridade, comercializa seguros de risco, seguros associados ao crédito e produtos de previdência através da rede de bancassurance. A CNP Seguros é outra seguradora detida pela CNP Assurances e pela Caixa Seguridade com uma carteira de seguros que inclui seguros habitacionais e a plataforma digital Youse. Por último existe a CNP Seguradora que gere uma operação controlada exclusivamente pela CNP Assurances que inclui, entre outras atividades, a Previsul e a CNP Capitalização. Desenvolve negócios fora da rede de distribuição da Caixa, nomeadamente através de outros canais e parceiros.

A venda faz parte da estratégia da Prudential Financial de reduzir a presença em mercados emergentes e concentrar capital nos Estados Unidos, Japão e alguns mercados europeus.

CBS News editor-in-chief Bari Weiss is taking heat from the left yet again, this time over a report urging her staff to probe Democratic Michigan Senate candidate Abdul El-Sayed's potential ties to the Muslim Brotherhood.

Semafor reported Sunday that Weiss "personally advocated for CBS News journalists to pursue numerous story angles related to El-Sayed’s supposed sympathy towards the Muslim Brotherhood."

The report cited two anonymous CBS News staffers who were aggrieved by Weiss' directive. Anonymous CBS News staffers complaining about their boss to liberal media outlets has become commonplace in the media industry. 

CONTROVERSY OVER ABDUL EL-SAYED'S FAMILY TIES TO MUSLIM BROTHERHOOD IGNORED, DOWNPLAYED BY LIBERAL MEDIA

NewsBusters executive editor Tim Graham believes disgruntled CBS News employees constantly offering anonymous quotes to liberal publications in an effort to smear Weiss "helps reinforce" the longstanding bias toward the left. 

"She’s making them do difficult things," Graham told Fox News Digital. 

"Can we look into whether Abdul El-Sayed has ties to the Muslim Brotherhood, like his family says they do? How dare you," Graham quipped. "You’re not supposed to do stories that might make Democrats look bad."

While Weiss’ defenders have suggested staffers are essentially irked that she asked them to do journalism, progressives lashed out against Weiss over the latest report.

"A rightwing, pro-Israel, anti-Muslim troll who has zero qualifications to be running national TV network is in fact running a national TV network and trying to get it to behave like a rightwing, pro-Israel, anti-Muslim troll," far-left Zeteo founder and former MSNBC host Mehdi Hasan reacted on X.

"No self-respecting journalist should work for Bari Weiss," The Nation correspondent Jeet Heer wrote.

"Nobody should respect or trust ANYTHING coming out of @CBSNews at this point," far-left activist Shaun King exclaimed.

Notably, CBS News largely refrained from covering the controversy that blew up last week when unearthed social media posts from his half-sister, Eman Abdelhadi, claimed their family, including their mother, had ties to the controversial Islamist group after he flatly denied there was any connection to NBC's Kristen Welker.

"Had an amazing talk with my mom about her activism in the Muslim Brotherhood during the early 70s while she was in college #respect," Abdelhadi wrote in a 2012 X post, as first reported by the Washington Free Beacon.

Their mother, Fatten Elkomy, had attended Egypt's Alexandria University, which, according to a report from the Brookings Institution, had strong Muslim Brotherhood activity back in the 1970s.

In another 2012 post, Abdelhadi, a professor at the University of Chicago, wrote, "My family has long been MB, but I've always felt that it has navigated the political sphere poorly/destructively."

In a third post from 2013, she wrote, "Praying for all my family that supports the #MB in #Egypt. Lie low, stay safe."

ABDUL EL-SAYED GROWS AGITATED WITH REPORTER AFTER BEING PRESSED ON FAMILY'S ALLEGED MUSLIM BROTHERHOOD TIES

Graham feels that CBS News staffers who didn’t want to look into the El-Sayed story must find it "wildly offensive" to even consider a conservative point of view. 

"They object [to] the idea that they have to be somehow a little bit fair and balanced," Graham said. 

As for El-Sayed, he recently doubled down on his denial during a contentious exchange with NBC's Tom Llamas.

"It's funny to me," El-Sayed responded. "I was born in 1984 down the street in Rochester Hills. I was raised here in Michigan, went to the University of Michigan, rebuilt the health department in this city, led the health department in this county — and you want to ask me about what's happening in Egypt in 1970? Are you serious?"

"I get it, but you were asked a question, and you gave an answer," Llamas responded.

"I have no ties, we have no ties," El-Sayed said, reiterating his denial.

CBS CHIEF BARI WEISS' INVOLVEMENT IN VIRAL EL-SAYED REPORT SPARKS DEBATE AMONG CRITICS

The Democratic hopeful told Llamas he hadn't had conversations with his mother about her alleged Muslim Brotherhood activity and accused the anchor of using "hearsay evidence from a tweet."

"That's just not serious," El-Sayed said.

"But you've also gone after the president for truthfulness and when people ask you a question, do you expect the truth?" Llamas then asked.

"Are you insinuating that somehow I was lying?" El-Sayed fired back.

"I don't know, that's why I'm asking," Llamas responded.

"And I'm telling you that I was not," El-Sayed told him.

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In an interview on MS NOW, El-Sayed likened the questions about his family allegiances to ones John F. Kennedy faced as a Catholic while running for president in 1960.

The American housing market deteriorated sharply in September as rising mortgage rates drove pending home sales to a record low and sent home construction tumbling, according to reports released Tuesday. The National Association of Realtors said its index of pending

The post Housing Slump Worsens Amid Higher Rates appeared first on Breitbart.

O presidente da Assembleia sublinha o facto de só se poder realizar um debate urgente numa quinzena, tendo o último ocorrido no dia 8. O Livre pediu reapreciação do antigo despacho de Aguiar-Branco.

© AMPE ROGÉRIO/LUSA

United Airlines CEO Scott Kirby backed national wealth and inheritance taxes in an interview published Sunday, arguing they would help level the playing field for Americans. Kirby told The New York Times that wealth inequality “has become a danger to our society,” adding the federal government must “address” it. “We should have a national wealth…

United Airlines CEO Scott Kirby backed national wealth and inheritance taxes in an interview published Sunday, arguing they would help level the playing field for Americans. Kirby told The New York Times that wealth inequality “has become a danger to our society,” adding the federal government must “address” it. “We should have a national wealth…

Nuovo sviluppo per la selezione pubblica indetta dall’Agenzia delle Entrate per la copertura a tempo indeterminato di 622 posti per Assistente Gestionale, riservata alle persone con disabilità iscritte al collocamento mirato (Legge 68/1999).

A seguito dell’accoglimento del ricorso da parte del Tribunale di Milano, che ha dichiarato discriminatoria la clausola della sola cittadinanza italiana con la sentenza n. 4273/2026, l’Agenzia ha disposto l’atto di modifica del bando con la riapertura dei termini di candidatura per i cittadini comunitari ed extra-Ue.

Chi può candidarsi con la riapertura dei termini

La nuova finestra temporale per l’invio delle domande è rivolta esclusivamente ai soggetti precedentemente esclusi dalla clausola sulla cittadinanza, purché in possesso di tutti gli altri requisiti previsti dal bando originario:

• cittadini di uno Stato membro dell’Unione Europea;
• familiari di cittadini Ue titolari del diritto di soggiorno o del diritto di soggiorno permanente;
• cittadini di Paesi terzi titolari del permesso di soggiorno Ue per soggiornanti di lungo periodo;
• cittadini di Paesi terzi titolari dello status di rifugiato o di protezione sussidiaria.

Per i candidati stranieri che non sono rifugiati né titolari di protezione sussidiaria, il godimento dei diritti civili e politici si riferisce al Paese di cittadinanza.

Requisiti generali e collocamento mirato

I candidati che presentano domanda tramite la riapertura dei termini dovevano possedere i seguenti requisiti già il 17 giugno 2026:

• iscrizione negli elenchi del collocamento mirato (art. 8, Legge 68/1999) della provincia per cui si concorre e stato di disoccupazione;
• diploma di scuola secondaria di secondo grado o titolo equipollente;
• età non inferiore ai 18 anni e posizione regolare nei confronti degli obblighi di leva (se dovuti);
• idoneità fisica allo svolgimento delle mansioni proprie della famiglia professionale di destinazione, compatibilmente con la disabilità posseduta.

Ciascun candidato può presentare domanda per una sola provincia, corrispondente a quella del servizio di collocamento mirato presso cui risulta iscritto.

Prove d’esame e nuove date per le istruzioni

L’iter selettivo prevede un’unica prova scritta della durata di 60 minuti, consistente in 50 quesiti a risposta multipla su elementi di diritto amministrativo, fini istituzionali dell’Agenzia delle Entrate, normativa sul pubblico impiego, informatica e lingua inglese. La prova si intende superata con una votazione minima di 18 su 30.

L’Agenzia delle Entrate ha comunicato che le indicazioni di dettaglio relative alla data, le sedi e la modalità di svolgimento della prova scritta saranno pubblicate sul sito istituzionale e sul Portale inPA il 15 dicembre 2026.

Modalità e nuova scadenza per le domande

Le nuove istanze di partecipazione devono essere inviate esclusivamente online attraverso il Portale unico del reclutamento inPA, autenticandosi tramite Spid, Cie, Cns o eIDAS e indicando un indirizzo di Posta Elettronica Certificata intestato al candidato.

La finestra temporale si chiude inderogabilmente alle ore 23:59 del 18 novembre 2026.

Altri concorsi attivi

Per chi è interessato alle opportunità d’inserimento nel settore pubblico a tempo pieno e indeterminato, resta aperta la possibilità di partecipare a diversi concorsi in scadenza ad ottobre, tra cui si menziona quello in Marina Militare.

The FBI investigated whether South Carolina’s late Sen. Lindsey Graham (R) and Rep. James Clyburn (D) were involved in a bribery scheme in connection to Hawaiian naval defense contractor Navatek acquiring federal contracts in their home state, according to a report published by ProPublica on Tuesday. The report states that Graham met with two executives…

The FBI investigated whether South Carolina’s late Sen. Lindsey Graham (R) and Rep. James Clyburn (D) were involved in a bribery scheme in connection to Hawaiian naval defense contractor Navatek acquiring federal contracts in their home state, according to a report published by ProPublica on Tuesday. The report states that Graham met with two executives…

A Federação Nacional dos Jornalistas (Fenaj) e seus sindicatos filiados manifestam indignação com a condução e o formato do debate eleitoral promovido pela TV Bandeirantes, na noite do último domingo (18).

O que deveria ser um espaço democrático de confronto de ideias, apresentação de propostas e esclarecimento dos eleitores, de acordo com a entidade, transformou-se em um espetáculo de provocações, bordões e ataques, em prejuízo da informação e do interesse público.

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Em nota, a Fenaj diz que “o jornalismo não pode ser refém da lógica do espetáculo, da audiência a qualquer preço ou das estratégias de candidatos que desprezam o diálogo democrático. Quando perguntas não são respondidas, afirmações falsas deixam de ser confrontadas e argumentos são substituídos por encenações, quem perde é a população brasileira”.

Liberdade de expressão não significa liberdade para transformar um debate jornalístico em instrumento de manipulação. E pluralidade não significa conceder às mentiras o mesmo tratamento dispensado aos fatos.

“Reconhecemos a trajetória dos profissionais responsáveis pela mediação, mas questionamos a responsabilidade editorial da emissora, a fragilidade das regras e a ausência de mecanismos capazes de assegurar a finalidade do debate. Não basta oferecer tempo igual aos candidatos. É indispensável garantir informações relevantes, fundamentadas e passíveis de verificação”, informa o documento.

O jornalismo não pode abdicar de sua responsabilidade de perguntar, confrontar versões, contextualizar acontecimentos e exigir respostas. A neutralidade diante da desinformação não representa imparcialidade. Ao contrário, pode contribuir para sua legitimação.

“É grave quando um debate favorece slogans e ataques pessoais, relegando a segundo plano temas fundamentais como saúde, educação, emprego, renda, desigualdade, segurança, soberania nacional, meio ambiente e direitos sociais. O futuro do país exige propostas concretas, não encenações destinadas à produção de cortes para as redes sociais”, avalia a Fenaj.

No documento, a Fenaj defende que as emissoras revejam seus modelos de debates eleitorais, com regras efetivas que assegurem respostas objetivas, intervenção editorial diante de informações comprovadamente falsas e responsabilização pelo descumprimento das normas”.

Não se trata de restringir o contraditório ou tutelar o pensamento dos eleitores, mas de assegurar o direito constitucional à informação de qualidade e impedir que a desinformação comprometa a liberdade de escolha.

“O Brasil conhece as consequências da normalização da mentira, da violência verbal e dos ataques às instituições democráticas. O jornalismo não pode ignorar essa experiência nem repetir práticas que transformaram a agressividade e a desinformação em instrumentos de disputa política”.

A nota afirma que “cabe às empresas de comunicação, aos profissionais e às entidades representativas reafirmar os princípios éticos do jornalismo. A informação é um direito da sociedade, não uma mercadoria subordinada aos interesses comerciais ou à busca de audiência”. Reafirmamos nosso compromisso histórico com a liberdade de imprensa, a ética profissional, o direito à informação e a defesa intransigente da democracia.

“Debate eleitoral não é entretenimento. Jornalismo não é espetáculo. Democracia não se constrói com mentiras. A sociedade brasileira merece debates à altura de seus desafios. E o jornalismo tem o dever de estar à altura de sua responsabilidade”, conclui o documento da Fenaj.

Applegate returned to the podcast she co-hosts with Jamie Lynn-Sigler to reveal the health news that is sending her for a loop: "You don't get misdiagnosed and then all of a sudden, I'm better. I haven't gotten better," she shares. "If anything, I've gotten worse in some ways."